The role of the glymphatic system in neurodegenerative disorders
The glymphatic system, which is most active during sleep, has recently been proposed as mediating waste clearance from the brain. Abnormal glymphatic transport could have broad consequences in normal brain physiology and in the diseased brain, including clearance toxic proteins in neurodegenerative disease and metabolic waste products. The objective of this study is to understand the role of the glymphatic system in neurodegenerative disorders, and whether modulating this system is possible to stop neurodegeneration. Across a programme of studies, we will use genetic, histological, immunological, clinical, neuropsychological and imaging markers to better understand mechanisms underlying glymphatic transport and evaluate whether modulation this system will improve clinical symptoms and disease progression.