Academic research at the NIG focuses on complex neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, Multiple Sclerosis, Huntington’s disease, Multiple System Atrophy, Progressive Supranuclear Palsy and Corticobasal degeneration. We are primarily using PET and MR imaging, and Clinical observation as methods of investigating aetiology, pathophysiology, and effects and complications of novel therapies in neurodegenerative disorders. We have a very wide portfolio of projects with the use of PET and MR imaging.
Our in vivo PET and MR imaging clinical research portfolio covers but is not limited to:
- Understanding the mechanisms underlying the development of motor and non-motor symptoms and complications in idiopathic and familial Parkinson’s disease
- The development of pre-symptomatic in vivo models for Parkinson’s disease
- Studies and identification of early and definite biomarkers in several neurodegenerative disorders such as Huntington’s disease
- In vivo detection and visualisation of primary and secondary pathology of atypical parkinsonian disorders such as Multiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal degeneration
- Identification of common and diverse mechanisms underlying the Dementia spectrum
- Understanding the aspects of neurodegeneration and myelin loss in Multiple Sclerosis
- Studies on effects and complications of novel therapies in neurodegenerative disorders
- Validation of new targets and novel methodology for analyses of imaging data in neurodegenerative disorders including the combined use of PET/MR imaging
Working with NIG, offers commercial organisations such as drug developers the possibility to access world-class expertise and imaging facilities. By employing imaging at early stages of drug development can save costs and time while improving disease understanding. We offer:
- Full end-to-end imaging solutions for clinical studies
- Support on specific elements of clinical studies
- Consultation on imaging studies and support in study design
- Development and assessment of PET and MRI techniques
- Analyses and interpretation of data from imaging studies
Our Team is delivering clinical service and running clinical trials at King’s College Hospitals. Our clinical research is taking place at the NIHR-Wellcome Trust King’s Clinical Research Facility, which is a state-of-the-art dedicated research environment for clinical research.
We offer private consultations to patients with movement disorders (e.g. Parkinson’s disease, Huntington’s disease, and atypical parkinsonian syndromes), memory problems (e.g. Mild Cognitive Impairment, Alzheimer’s disease) and Multiple Sclerosis.
Teaching & Training
At NIG, Team members and visiting researchers gain intense training in clinical research and in analysis and interpretation of PET, and structural and functional MR imaging data. There is a wide range of imaging software we access and use including Matlab, Statistical Parametric Mapping (SPM), FMRIB Software Library (FSL), Molecular Imaging and Kinetic Analysis Toolbox (MIAKAT™), ANALYZE, FreeSurfer and others.
At IoPPN, King’s College London, the NIG Team is significantly contributing to academic teaching of students with lectures, tutorials, practicals, bedside teaching, seminars and organizational roles in several courses and programmes including the MSc Clinical Neuroscience, MSc Neuroimaging, Clinical Neurology for MBBS Medical students, and BSc Biochemistry.